I Am Omega (2007)
In a post apocalyptic world ravaged by disease, embittered survivor Renchard (Mark Dacascos) leads a life of solitude dedicated to the destruction of the mutated plague victims that killed his wife and son.
Having planted high-explosive time-bombs all over the city where the zombie-like creatures now reside, Renchard is forced by two highly trained special forces soldiers, Mike and Vincent (Ryan Lloyd and Geoff Meed), to lead a dangerous mission into zombie central to rescue immune damsel in distress Brianna (Jennifer Lee Wiggins), who might just hold the answer to a cure for the epidemic. (IMDB BA_Harrison)
The novel [I Am Legend] was a success and was adapted to film as The Last Man on Earth in 1964, as The Omega Man in 1971, and as I Am Legend in 2007, along with a direct-to-video 2007 production capitalizing on that film, I Am Omega. The novel was also the inspiration behind the 1968 film Night of the Living Dead.